Un De Sceaux will face just four rivals as he bids for a third successive victory in the Royal Salute Whisky Clarence House Chase at Ascot on Saturday.
Willie Mullins' raider won the event when it was run at Cheltenham last year and victory here would see him become the first triple winner of the race.
However, Nicky Henderson's Brain Power has attracted plenty of support throughout the week and the novice, who will be having just his third outing over fences, leads the opposition.
Nigel Hawke's Speredek takes a huge leap in company after winning five of his last six handicap starts, while Paul Nicholls fields San Benedeto, who was last of five finishers in the Tingle Creek on his most recent outing.
The Harry Fry-trained Kylemore Lough, a Grade One winner for Kerry Lee in 2016, completes the field as he tries to bounce back from a disappointing reappearance at Cheltenham in November.